U.S. Route 22 will be reconstructed in a series of small sections. The internal 'names' given to each section of this highway are in a series ranging from B01 through B10. The following explanation is intended to give some orientation to the locations of each respective section.

Section B01 - Begins at the Allegheny/Westmoreland County Line and extends through the main portion of the Municipality of Murrysville to east of the Cozy Inn Cut-Off.  Completed in 2005. 

Section B02 - Begins east of the Cozy Inn Cut-Off in the Municipality of Murrysville and extends east to near the Route 22/66 Interchange in Salem Township. This portion of Route 22 was included in the environmental studies referred to as Section B04 (which included Sections B01 & B02). 

Section B03 - Includes the Route 22/66 Single Point Urban Interchange (SPUI) in Salem Township and State Route 66 north to Delmont Borough. Completed in 2000. 

Section B04 - This portion of Route 22 was included in the environmental studies which included Sections B01 & B02. A detailed description of these individual highway segments is included within those respective sections. 

Section B05 - Begins at the Route 22/66 Interchange in Salem Township and extends to the Route 22/819 Intersection at Five Points in Salem Township. Completed reconstruction in 1994. 

Section B06 - Begins at the Route 22/819 Intersection at Five Points in Salem Township and extends to near the Route 22/119 Interchange at Shieldsburg in Salem Township. Completed reconstruction in 1995. 

Section B07 - Begins near the Route 22/119 Interchange at Shieldsburg in Salem Township and extends through the intersection of Route 22/981 in the Borough of New Alexandria. Completed in 2003. 

Section B08 - Begins east of the intersection of Route 22/981 in the Borough of New Alexandria and extends to the intersection of Route 22/982 in Derry Township. 

Section B09 - Begins at the intersection of Route 22/982 in Derry Township and extends to the Route 22/Township Road 693 (Auction Barn Road) intersection. 

Section B10 - Begins at the intersection of Route 22/Township Road 693 (Auction Barn Road) and extends to the Route 22/State Route 217 intersection just east of the Conemaugh River Bridge.